Some new, some old, observations about the mismanagement of depression. Good just for the highlights. Full paper here:

Depression is neither disease nor disorder rather an adaptation that evolved to serve a purpose

Depression is so much more prevalent than currently recognized that it is “species typical”

Antidepressants drive neurotransmitter levels so high that homeostatic regulation kicks in

Antidepressants may suppress symptoms in a manner that increases risk for subsequent relapse

Cognitive therapy works by making rumination more efficient and “unsticking” self-blame

Adding antidepressants may interfere with any enduring effect that cognitive therapy may have