A personalised alternative to antidepressants is on the way:

the treatment of depression is currently evolving in unexpected ways. This is based on a shift away from thinking about depression as a disorder of ‘chemicals in the brain’ to an understanding that depression is underpinned by changes in electrical activity and communication between brain regions.

but

At times, this resistance seems to reflect a perhaps wilful ignorance of evidence or even an ideological approach to medicine rather than an evidence-based one. There is a danger that a highly novel treatment, such as home-based closed-loop stimulation, will produce a similar degree of professional resistance, especially given that treatment informed by artificial intelligence could be seen to reduce the role of the clinician in the decision-making process.